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Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC , the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts

Curr Opin Pharmacol 7:360366

I.JurisicovaA.PruJ

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used computer modeling and molecular docking to find that the 7-9 N-terminal amino acids of hepcidin, including a single mercaptocysteine, constitute the minimum structure required to retain the activity of hepcidin

[12] shown that joint effect between high exposure to second hand smoking and low omega-3 PUFA intake level on metabolic syndrome risk among children was stronger than would be expected from the effects of the single exposure factor